A Comparison of Muscle Function, Mass, and Quality in Liver Transplant Candidates: Results From the Functional Assessment in Liver Transplantation Study.

ABSTRACT:

Background

Sarcopenia and functional impairment are common and lethal extrahepatic manifestations of cirrhosis. We aimed to determine the association between computed tomography (CT)-based measures of muscle mass and quality (sarcopenia) and performance-based measures of muscle function.

Methods

Adults listed for liver transplant underwent testing of muscle function (grip strength, Short Physical Performance Battery [SPPB]) within 3 months of abdominal CT. Muscle mass (cm/m) = total cross-sectional area of psoas, paraspinal, and abdominal wall muscles at L3 on CT, normalized for height. Muscle quality = mean Hounsfield units for total skeletal muscle area at L3.

Results

Among 292 candidates, median grip strength was 31 kg, SPPB score was 11, muscle mass was 49 cm/m, a

SUBMITTER: Wang CW 

PROVIDER: S-EPMC4962324 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature