Immunogenetics of cutaneous lupus erythematosus.

ABSTRACT:

Purpose of review

Systemic lupus erythematosus (SLE) is the prototypic autoimmune condition, often affecting multiple organ systems, including the skin. Cutaneous lupus erythematosus (CLE) is distinct from SLE and may be skin limited or associated with systemic disease. Histopathologically, the hallmark of lupus-specific manifestations of SLE and CLE is an interface dermatitis. The cause of SLE and CLE is likely multifactorial and may include shared genetic factors. In this review, we will discuss the genetic findings related to the cutaneous manifestations of SLE and isolated CLE, with a particular focus on the lupus-specific CLE subtypes.

Recent findings

Several major histocompatibility complex and nonmajor histocompatibility complex genetic polymorphisms have been identif

SUBMITTER: Hersh AO 

PROVIDER: S-EPMC4962329 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature