Association study of C-reactive protein associated gene HNF1A with ischemic stroke in Chinese population.

ABSTRACT:

Background

Ischemic stroke is a life-threatening condition due to obstructed blood supply of the brain. Elevation of plasma C-reactive protein, an important inflammatory marker, was known to associate with increased risk of ischemic stroke. Previous studies reported association between genetic variants of HNF1A and plasma level of C-reactive protein. The HNF1A gene encodes a hepatocyte transcription factor which might have regulatory effects on C-reactive protein synthesis in liver. Therefore, the C-reactive protein associated gene HNF1A seems to be a promising candidate gene for ischemic stroke.

Results

We used HNF1A as a candidate gene of ischemic stroke and evaluated seven common variants of HNF1A for their contribution to ischemic stroke. The association analysis of HNF1

SUBMITTER: Shi H 

PROVIDER: S-EPMC4962403 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature