Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the most common malignancies and a leading cause of cancer death worldwide. Most cancer cells display high rates of glycolysis with production of lactic acid, which is then exported to the microenvironment by monocarboxylate transporters (MCTs). The main aim of this study was to evaluate the significance of MCT expression in a comprehensive series of primary CRC cases, lymph node and hepatic metastasis.

Methods

Expressions of MCT1, MCT4, CD147 and GLUT1 were studied in human samples of CRC, lymph node and hepatic metastasis, by immunohistochemistry.

Results

All proteins were overexpressed in primary CRC, lymph node and hepatic metastasis, when compared with non-neoplastic tissue, with exception of MCT1 in lymph node and hep

SUBMITTER: Martins SF 

PROVIDER: S-EPMC4962413 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature