Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells.

ABSTRACT:

Background

Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased approach to identify pathways activated in bronchoalveolar lavage (BAL) cells can shed light on the pathogenesis of this complex disease.

Methods

We recruited 15 patients with various stages of sarcoidosis and 12 healthy controls. All subjects underwent bronchoscopy with lavage. For each subject, total RNA was extracted from BAL cells and hybridized to an Affymetrix U133A microarray. Rigorous statistical methods were applied to identify differential gene expression between subjects with sarcoidosis vs.

Controls

To better elucidate pathways differentially activated between these groups, we integrated network an

SUBMITTER: Gharib SA 

PROVIDER: S-EPMC4962428 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature