Associations between microvascular function and short-term exposure to traffic-related air pollution and particulate matter oxidative potential.

ABSTRACT:

Background

Short-term exposure to ambient air pollution has been associated with acute increases in cardiovascular hospitalization and mortality. However, causative chemical components and underlying pathophysiological mechanisms remain to be clarified. We hypothesized that endothelial dysfunction would be associated with mobile-source (traffic) air pollution and that pollutant components with higher oxidative potential to generate reactive oxygen species (ROS) would have stronger associations.

Methods

We carried out a cohort panel study in 93 elderly non-smoking adults living in the Los Angeles metropolitan area, during July 2012-February 2014. Microvascular function, represented by reactive hyperemia index (RHI), was measured weekly for up to 12 weeks (N = 845). Air pollut

SUBMITTER: Zhang X 

PROVIDER: S-EPMC4962442 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature