Maternal exposure to diluted diesel engine exhaust alters placental function and induces intergenerational effects in rabbits.

ABSTRACT:

Background

Airborne pollution is a rising concern in urban areas. Epidemiological studies in humans and animal experiments using rodent models indicate that gestational exposure to airborne pollution, in particular diesel engine exhaust (DE), reduces birth weight, but effects depend on exposure duration, gestational window and nanoparticle (NP) concentration. Our aim was to evaluate the effects of gestational exposure to diluted DE on feto-placental development in a rabbit model. Pregnant females were exposed to diluted (1 mg/m(3)), filtered DE (NP diameter ≈ 69 nm) or clean air (controls) for 2 h/day, 5 days/week by nose-only exposure (total exposure: 20 days in a 31-day gestation).

Results

DE exposure induced early signs of growth retardation at mid gestation with decrease

SUBMITTER: Valentino SA 

PROVIDER: S-EPMC4962477 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature