A QTL on 12q influencing an inflammation marker and obesity in white women: the NHLBI Family Heart Study.

ABSTRACT: It has been recognized that obese individuals are intrinsically in a state of chronic inflammation, as indicated by positive correlations between serum levels of C-reactive protein (CRP) and various anthropometric measures of obesity. To explore the hypothesis that a gene(s) may underlie this relationship, we conducted bivariate linkage analyses of BMI and CRP in white and African-American (AA) families of the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study (FHS). Variance components linkage analysis as implemented in SOLAR was performed in 1,825 whites (840 men and 985 women) and 548 AAs (199 men and 351 women). CRP exhibited significant genetic correlations with BMI in women (0.54 +/- 0.10 for white and 0.53 +/- 0.14 for AA) and the combined samples (0.37 +/- 0.09 fo

SUBMITTER: Wu J 

PROVIDER: S-EPMC4962615 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature