Protein models: the Grand Challenge of protein docking.

ABSTRACT: Characterization of life processes at the molecular level requires structural details of protein-protein interactions (PPIs). The number of experimentally determined protein structures accounts only for a fraction of known proteins. This gap has to be bridged by modeling, typically using experimentally determined structures as templates to model related proteins. The fraction of experimentally determined PPI structures is even smaller than that for the individual proteins, due to a larger number of interactions than the number of individual proteins, and a greater difficulty of crystallizing protein-protein complexes. The approaches to structural modeling of PPI (docking) often have to rely on modeled structures of the interactors, especially in the case of large PPI networks. Structures o

SUBMITTER: Anishchenko I 

PROVIDER: S-EPMC4962618 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature