Seven-Year Efficacy of RTS,S/AS01 Malaria Vaccine among Young African Children.

ABSTRACT:

Background

The candidate malaria vaccine RTS,S/AS01 is being evaluated in order to inform a decision regarding its inclusion in routine vaccination schedules.

Methods

We conducted 7 years of follow-up in children who had been randomly assigned, at 5 to 17 months of age, to receive three doses of either the RTS,S/AS01 vaccine or a rabies (control) vaccine. The end point was clinical malaria (temperature of ≥37.5°C and infection with Plasmodium falciparum of >2500 parasites per cubic millimeter). In an analysis that was not prespecified, the malaria exposure of each child was estimated with the use of information on the prevalence of malaria among residents within a 1-km radius of the child's home. Vaccine efficacy was defined as 1 minus the hazard ratio or the incidence-rate

SUBMITTER: Olotu A 

PROVIDER: S-EPMC4962898 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature