Distending Pressure Did Not Activate Acute Phase or Inflammatory Responses in the Airways and Lungs of Fetal, Preterm Lambs.

ABSTRACT:

Background

Mechanical ventilation at birth causes airway injury and lung inflammation in preterm sheep. Continuous positive airway pressure (CPAP) is being increasingly used clinically to transition preterm infants at birth.

Objective

To test if distending pressures will activate acute phase reactants and inflammatory changes in the airways of fetal, preterm lambs.

Methods

The head and chest of fetal lambs at 128±1 day GA were surgically exteriorized. With placental circulation intact, fetal lambs were then randomized to one of five 15 minute interventions: PEEP of 0, 4, 8, 12, or 16 cmH2O. Recruitment volumes were recorded. Fetal lambs remained on placental support for 30 min after the intervention. The twins of each 0 cmH2O animal served as controls. Fetal lung flui

SUBMITTER: Petersen RY 

PROVIDER: S-EPMC4962990 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature