ADAMTS14 Gene Polymorphism and Environmental Risk in the Development of Oral Cancer.

ABSTRACT:

Background

Oral cancer is a common malignancy that is shown to be causally associated with hereditary and acquired factors. ADAMTS14 is a member of the ADAMTS (a disintegrin-like and metalloproteinase domain with thrombospondin motifs) metalloproteinase family that plays an important role in extracellular matrix (ECM) assembly and degradation. Elevation or deficiency of certain ADAMTS proteinases has been known to be implicated in a wide range of pathological processes including atherosclerosis, arthritis, and cancer. The present study aimed to explore the impact of ADAMTS14 gene polymorphisms, combined with environmental risks on the susceptibility to oral tumorigenesis.

Methodology/principal findings

Four single-nucleotide polymorphisms (SNPs) of the ADAMTS14 gene, includi

SUBMITTER: Su SC 

PROVIDER: S-EPMC4962993 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature