Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages.

ABSTRACT: Macrophages are cells with remarkable plasticity. They integrate signals from their microenvironment leading to context-dependent polarization into classically (M1) or alternatively (M2) activated macrophages, representing two extremes of a broad spectrum of divergent phenotypes. Thereby, macrophages deliver protective and pro-regenerative signals towards injured tissue but, depending on the eliciting damage, may also be responsible for the generation and aggravation of tissue injury. Although incompletely understood, there is emerging evidence that macrophage polarization is critical for these antagonistic roles. To identify activation-specific expression patterns of chemokines and cytokines that may confer these distinct effects a systems biology approach was applied. A comprehensive lit

SUBMITTER: Rex J 

PROVIDER: S-EPMC4963125 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature