Polygenic risk score is associated with increased disease risk in 52 Finnish breast cancer families.

ABSTRACT: The risk of developing breast cancer is increased in women with family history of breast cancer and particularly in families with multiple cases of breast or ovarian cancer. Nevertheless, many women with a positive family history never develop the disease. Polygenic risk scores (PRSs) based on the risk effects of multiple common genetic variants have been proposed for individual risk assessment on a population level. We investigate the applicability of the PRS for risk prediction within breast cancer families. We studied the association between breast cancer risk and a PRS based on 75 common genetic variants in 52 Finnish breast cancer families including 427 genotyped women and pedigree information on ~4000 additional individuals by comparing the affected to healthy family members, as well

SUBMITTER: Muranen TA 

PROVIDER: S-EPMC4963452 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature