Determining the Effective Density and Stabilizer Layer Thickness of Sterically Stabilized Nanoparticles.

ABSTRACT: A series of model sterically stabilized diblock copolymer nanoparticles has been designed to aid the development of analytical protocols in order to determine two key parameters: the effective particle density and the steric stabilizer layer thickness. The former parameter is essential for high resolution particle size analysis based on analytical (ultra)centrifugation techniques (e.g., disk centrifuge photosedimentometry, DCP), whereas the latter parameter is of fundamental importance in determining the effectiveness of steric stabilization as a colloid stability mechanism. The diblock copolymer nanoparticles were prepared via polymerization-induced self-assembly (PISA) using RAFT aqueous emulsion polymerization: this approach affords relatively narrow particle size distributions and enab

SUBMITTER: Akpinar B 

PROVIDER: S-EPMC4963924 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature