Characterization of VP1 sequence of Coxsackievirus A16 isolates by Bayesian evolutionary method.

ABSTRACT:

Background

Coxsackievirus A16 (CV-A16), a major etiopathologic cause of pediatric hand, foot, and mouth disease (HFMD) worldwide, has been reported to have caused several fatalities. Revealing the evolutionary and epidemiologic dynamics of CV-A16 across time and space is central to understanding its outbreak potential.

Methods

In this study, we isolated six CV-A16 strains in China's Jilin province and construct a maximum clade credibility (MCC) tree for CV-A16 VP1 gene by the Bayesian Markov Chain Monte Carlo method using 708 strains from GenBank with epidemiological information. The evolution characteristics of CV-A16 VP1 gene was also analysed dynamicly through Bayesian skyline plot.

Results

All CV-A16 strains identified could be classified into five major genogroup

SUBMITTER: Zhao G 

PROVIDER: S-EPMC4963925 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature