Palmitate-induced ER stress increases trastuzumab sensitivity in HER2/neu-positive breast cancer cells.

ABSTRACT:

Background

HER2/neu-positive breast cancer cells have recently been shown to use a unique Warburg-like metabolism for survival and aggressive behavior. These cells exhibit increased fatty acid synthesis and storage compared to normal breast cells or other tumor cells. Disruption of this synthetic process results in apoptosis. Since the addition of physiological doses of exogenous palmitate induces cell death in HER2/neu-positive breast cancer cells, the pathway is likely operating at its limits in these cells. We have studied the response of HER2/neu-positive breast cancer cells to physiological concentrations of exogenous palmitate to identify lipotoxicity-associated consequences of this physiology. Since epidemiological data show that a diet rich in saturated fatty acids is negat

SUBMITTER: Baumann J 

PROVIDER: S-EPMC4964104 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature