Compound K Attenuates the Development of Atherosclerosis in ApoE(-/-) Mice via LXRα Activation.

ABSTRACT: Atherosclerosis is a fundamental pathological process responded to some serious cardiovascular events. Although the cholesterol-lowering drugs are widely prescribed for atherosclerosis therapy, it is still the leading cause of death in the developed world. Here we measured the effects of compound K in atherosclerosis formation and investigated the probably mechanisms of the anti-antherosclerosis roles of compound K. We treated the atherosclerotic model animals (apoE(-/-) mice on western diet) with compound K and measured the size of atherosclerotic lesions, inflammatory cytokine levels and serum lipid profile. Peritoneal macrophages were collected in vitro for the foam cell and inflammasome experiments. Our results show that treatment with compound K dose-dependently attenuates the formati

SUBMITTER: Zhou L 

PROVIDER: S-EPMC4964430 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature