Compound K Attenuates the Development of Atherosclerosis in ApoE(-/-) Mice via LXR? Activation.

ABSTRACT:

Background

Atherosclerosis is a fundamental pathological process responded to some serious cardiovascular events. Although the cholesterol-lowering drugs are widely prescribed for atherosclerosis therapy, it is still the leading cause of death in the developed world. Here we measured the effects of compound K in atherosclerosis formation and investigated the probably mechanisms of the anti-antherosclerosis roles of compound K.

Methods

We treated the atherosclerotic model animals (apoE(-/-) mice on western diet) with compound K and measured the size of atherosclerotic lesions, inflammatory cytokine levels and serum lipid profile. Peritoneal macrophages were collected in vitro for the foam cell and inflammasome experiments.

Results

Our results show that treatment with compound K dose-dependently attenuates the formation of atherosclerotic plaques by 55% through activation of reverse cholesterol transport pathway, reduction of systemic inflammatory cytokines and inhibition of local inflammasome activity. Compound K increases the cholesterol efflux of macrophage-derived foam cells, and reduces the inflammasome activity in cholesterol crystal stimulated macrophages. The activation of LXR? may contribute to the athero-protective effects of compound K.

Conclusion

These observations provide evidence for an athero-protective effect of compound K via LXR? activation, and support its further evaluation as a potential effective modulator for the prevention and treatment of atherosclerosis.

SUBMITTER: Zhou L 

PROVIDER: S-EPMC4964430 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature