Human Aquaporin-4 and Molecular Modeling: Historical Perspective and View to the Future.

ABSTRACT: Among the different aquaporins (AQPs), human aquaporin-4 (hAQP4) has attracted the greatest interest in recent years as a new promising therapeutic target. Such a membrane protein is, in fact, involved in a multiple sclerosis-like immunopathology called Neuromyelitis Optica (NMO) and in several disorders resulting from imbalanced water homeostasis such as deafness and cerebral edema. The gap of knowledge in its functioning and dynamics at the atomistic level of detail has hindered the development of rational strategies for designing hAQP4 modulators. The application, lately, of molecular modeling has proved able to fill this gap providing a breeding ground to rationally address compounds targeting hAQP4. In this review, we give an overview of the important advances obtained in this field t

SUBMITTER: Mangiatordi GF 

PROVIDER: S-EPMC4964494 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature