Peripheral biomarkers revisited: integrative profiling of peripheral samples for psychiatric research.

ABSTRACT: Peripheral samples, such as blood and skin, have been used for decades in psychiatric research as surrogates for central nervous system samples. Although the validity of the data obtained from peripheral samples has been questioned and other state-of-the-art techniques, such as human brain imaging, genomics, and induced pluripotent stem cells, seem to reduce the value of peripheral cells, accumulating evidence has suggested that revisiting peripheral samples is worthwhile. Here, we re-evaluate the utility of peripheral samples and argue that establishing an understanding of the common signaling and biological processes in the brain and peripheral samples is required for the validity of such models. First, we present an overview of the available types of peripheral cells and describe their

SUBMITTER: Hayashi-Takagi A 

PROVIDER: S-EPMC4964959 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature