Revisiting the Robustness of PET-Based Textural Features in the Context of Multi-Centric Trials.

ABSTRACT:

Purpose

This study aimed to investigate the variability of textural features (TF) as a function of acquisition and reconstruction parameters within the context of multi-centric trials.

Methods

The robustness of 15 selected TFs were studied as a function of the number of iterations, the post-filtering level, input data noise, the reconstruction algorithm and the matrix size. A combination of several reconstruction and acquisition settings was devised to mimic multi-centric conditions. We retrospectively studied data from 26 patients enrolled in a diagnostic study that aimed to evaluate the performance of PET/CT 68Ga-DOTANOC in gastro-entero-pancreatic neuroendocrine tumors. Forty-one tumors were extracted and served as the database. The coefficient of variation (COV) or the a

SUBMITTER: Bailly C 

PROVIDER: S-EPMC4965162 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature