Overview of pathophysiology and treatment of human lupus nephritis.

ABSTRACT:

Purpose of review

Despite recent developments and treatment successes, the outcome, and prognosis of patients with lupus nephritis (LuN) have not greatly changed since the 1980s. This review covers the application of new concepts to the understanding of renal inflammation and the study of new pharmacologic agents to improve patient outcomes.

Recent findings

Studies have shown that the presence of anti-vimentin antibodies and T follicular helper cells in patient biopsies is associated with more severe interstitial inflammation, which has been tied to faster disease progression and onset of end-stage renal disease. Additionally, data regarding the role of serum IgE antidouble-stranded DNA antibodies in LuN by means of mediating IFN1 production by plasmacytoid dendritic cells a

SUBMITTER: Trotter K 

PROVIDER: S-EPMC4965286 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature