White matter alterations in individuals experiencing attenuated positive psychotic symptoms.

ABSTRACT:

Aim

Diffusion tensor imaging (DTI) studies suggest that reduced fractional anisotropy (FA) in the inferior longitudinal fasciculus (ILF) and superior longitudinal fasciculus (SLF) occurs among schizophrenia patients and those at risk for psychosis. Nevertheless, there is a dearth of knowledge investigating white matter fibre pathways in non-help-seeking individuals who endorse attenuated positive psychotic symptoms (APPS) across a range of mental disorders. The aim of the current study was to determine if alterations in ILF and SLF microstructures were specific to distressing APPS related to risk for psychosis or to APPS symptoms occurring in multiple mental disorders, which would suggest a shared phenotype among disorders.

Method

Twenty-six non-help-seeking young adults wer

SUBMITTER: Cooper S 

PROVIDER: S-EPMC4965329 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature