Distinct intracellular signaling mediates C-MET regulation of dendritic growth and synaptogenesis.

ABSTRACT: Hepatocyte growth factor (HGF) activation of the MET receptor tyrosine kinase influences multiple neurodevelopmental processes. Evidence from human imaging and mouse models shows that, in the forebrain, disruptions in MET signaling alter circuit formation and function. One likely means of modulation is by controlling neuron maturation. Here, we examined the signaling mechanisms through which MET exerts developmental effects in the neocortex. In situ hybridization revealed that hgf is located near MET-expressing neurons, including deep neocortical layers and periventricular zones. Western blot analyses of neocortical crude membranes demonstrated that HGF-induced MET autophosphorylation peaks during synaptogenesis, with a striking reduction in activation between P14 and P17 just before pruni

SUBMITTER: Eagleson KL 

PROVIDER: S-EPMC4965336 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature