Update and New Directions in Therapeutics for Neurological Complications of HIV Infections.

ABSTRACT: The pace of therapeutic developments in HIV presents unique challenges to the neurologist caring for patients. Combination antiretroviral therapy (cART) is remarkably effective in suppressing viral replication, preventing, and often even reversing disease progression. Still, not every patient benefits from cART for a variety of reasons, ranging from the cost of therapy and the burden of lifelong daily treatment to side effects and inadequate access to medical care. Treatment failure inevitably leads to disease progression and opportunistic complications. Many of these complications, even those that are treatable, produce permanent neurological disability. With ART, immune recovery itself may paradoxically lead to severe neurological disease; strategies for managing so-called immune reconst

SUBMITTER: Ellis R 

PROVIDER: S-EPMC4965416 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature