Identification of clinically achievable combination therapies in childhood rhabdomyosarcoma.

ABSTRACT:

Purpose

Systemic therapy has improved rhabdomyosarcoma event-free and overall survival; however, approximately 40 % of patients will have progressive or recurrent disease which is difficult to cure and remains a considerable challenge. Minimal progress has been made in improving outcomes for metastatic or relapsed RMS due to a lack of effective therapeutic agents. Targeted therapies are likely to be incorporated into regimens which rely on conventional cytotoxic chemotherapy. A system to evaluate novel combinations of interest is needed.

Methods

In this study, we explored 8 agents, 5 that are routinely used or similar to agents used in the clinical management of RMS and 3 biologically targeted agents with novel mechanisms of action, the Wee1 inhibitor AZD1775, the tyrosine k

SUBMITTER: Kahen E 

PROVIDER: S-EPMC4965487 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature