The spatiotemporal order of signaling events unveils the logic of development signaling.

ABSTRACT:

Motivation

Animals from worms and insects to birds and mammals show distinct body plans; however, the embryonic development of diverse body plans with tissues and organs within is controlled by a surprisingly few signaling pathways. It is well recognized that combinatorial use of and dynamic interactions among signaling pathways follow specific logic to control complex and accurate developmental signaling and patterning, but it remains elusive what such logic is, or even, what it looks like.

Results

We have developed a computational model for Drosophila eye development with innovated methods to reveal how interactions among multiple pathways control the dynamically generated hexagonal array of R8 cells. We obtained two novel findings. First, the coupling between the long-ran

SUBMITTER: Zhu H 

PROVIDER: S-EPMC4965629 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature