Association of CACNA1C Variants with Bipolar Disorder in the Korean Population.

ABSTRACT:

Objective

Previous studies have suggested an association between CACNA1C and susceptibility of bipolar disorder. In this study, we examined the association of CACNA1C variants with bipolar disorder in the Korean population.

Methods

We selected 2 CACNA1C single nucleotide polymorphisms (SNPs), namely, rs723672 and rs1051375, based on their functions and minor allele frequencies described in previous studies. Genotypes of these 2 SNPs were analyzed by extracting DNA from blood samples collected from 287 patients with bipolar disorder and 340 healthy controls.

Results

Genotype frequencies of both rs723672 and rs1051375 SNPs were significantly different in patients and controls (p=0.0462 and 1.732E-14, respectively). Dominant, recessive, and allele models showed significa

SUBMITTER: Kim S 

PROVIDER: S-EPMC4965657 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature