Reduced Protein Synthesis Fidelity Inhibits Flagellar Biosynthesis and Motility.

ABSTRACT: Accurate translation of the genetic information from DNA to protein is maintained by multiple quality control steps from bacteria to mammals. Genetic and environmental alterations have been shown to compromise translational quality control and reduce fidelity during protein synthesis. The physiological impact of increased translational errors is not fully understood. While generally considered harmful, translational errors have recently been shown to benefit cells under certain stress conditions. In this work, we describe a novel regulatory pathway in which reduced translational fidelity downregulates expression of flagellar genes and suppresses bacterial motility. Electron microscopy imaging shows that the error-prone Escherichia coli strain lacks mature flagella. Further genetic analyses

SUBMITTER: Fan Y 

PROVIDER: S-EPMC4965754 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature