The origin of chromosomal inversions as a source of segmental duplications in the Sophophora subgenus of Drosophila.

ABSTRACT: Chromosomal inversions can contribute to the adaptation of organisms to their environment by capturing particular advantageous allelic combinations of a set of genes included in the inverted fragment and also by advantageous functional changes due to the inversion process itself that might affect not only the expression of flanking genes but also their dose and structure. Of the two mechanisms originating inversions -ectopic recombination, and staggered double-strand breaks and subsequent repair- only the latter confers the inversion the potential to have dosage effects and/or to generate advantageous chimeric genes. In Drosophila subobscura, there is ample evidence for the adaptive character of its chromosomal polymorphism, with an important contribution of some warm-climate arrangements

SUBMITTER: Puerma E 

PROVIDER: S-EPMC4965816 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature