Glycation Reactivity of a Quorum-Sensing Signaling Molecule.

ABSTRACT: Reported herein is that (4S)-4,5-dihydroxy-2,3-pentanedione (DPD) can undergo a previously undocumented non-enzymatic glycation reaction. Incubation of DPD with viral DNA or the antibiotic gramicidin S resulted in significant biochemical alterations. A protein-labeling method was consequently developed that facilitated the identification of unrecognized glycation targets of DPD in a prokaryotic system. These results open new avenues toward tracking and understanding the fate and function of the elusive quorum-sensing signaling molecule.

SUBMITTER: Tsuchikama K 

PROVIDER: S-EPMC4965832 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature