Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells.

ABSTRACT:

Background

Recent genetic studies in model organisms, such as Drosophila, C. elegans and mice, have highlighted a critical role for dual leucine zipper kinase (DLK) in neural development and axonal responses to injury. However, exactly how DLK fulfills these functions remains to be determined. Using RNA-seq profiling, we evaluated the global changes in gene expression that are caused by shRNA-mediated knockdown of endogenous DLK in differentiated Neuro-2a neuroblastoma cells.

Results

Our analysis led to the identification of numerous up- and down-regulated genes, among which several were found to be associated with system development and axon guidance according to gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses, respectively. Because of

SUBMITTER: Blondeau A 

PROVIDER: S-EPMC4965899 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature