Driver Mutations in Uveal Melanoma: Associations With Gene Expression Profile and Patient Outcomes.

ABSTRACT:

Importance

Frequent mutations have been described in the following 5 genes in uveal melanoma (UM): BAP1, EIF1AX, GNA11, GNAQ, and SF3B1. Understanding the prognostic significance of these mutations could facilitate their use in precision medicine.

Objective

To determine the associations between driver mutations, gene expression profile (GEP) classification, clinicopathologic features, and patient outcomes in UM.

Design, setting, and participants

Retrospective study of patients with UM treated by enucleation by a single ocular oncologist between November 1, 1998, and July 31, 2014.

Main outcomes and measures

Clinicopathologic features, patient outcomes, GEP classification (class 1 or class 2), and mutation status were recorded.

Results

The study cohort co

SUBMITTER: Decatur CL 

PROVIDER: S-EPMC4966162 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature