Prognostic parameters in uveal melanoma and their association with BAP1 expression.

ABSTRACT:

Aim

To determine whether BAP1 gene and protein expression associates with different prognostic parameters in uveal melanoma and whether BAP1 expression correctly identifies patients as being at risk for metastases, following enucleation of the primary tumour.

Methods

Thirty cases of uveal melanoma obtained by enucleation between 1999 and 2004 were analysed for a variety of prognostic markers, including histological characteristics, chromosome aberrations obtained by fluorescence in situ hybridisation (FISH) and single nucleotide polymorphism (SNP) analysis and gene expression profiling. These parameters were compared with BAP1 gene expression and BAP1 immunostaining.

Results

The presence of monosomy of chromosome 3 as identified by the different chromosome 3 tests sho

SUBMITTER: van Essen TH 

PROVIDER: S-EPMC4966163 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature