Prognostic Implications of Tumor Diameter in Association With Gene Expression Profile for Uveal Melanoma.

ABSTRACT:

Importance

Uveal melanoma (UM) can be divided into prognostically significant subgroups based on a prospectively validated and widely used 15-gene expression profile (GEP) test. Class 1 UMs have a low risk and class 2 UMs have a high risk for metastasis.

Objective

To determine whether any clinicopathologic factors provide independent prognostic information that may enhance the accuracy of the GEP classification.

Design, setting, and participants

This retrospective observational study performed at 2 ocular oncology referral centers included 339 patients in a primary cohort and 241 patients in a validation cohort. Both cohorts had a diagnosis of UM arising from the ciliary body and/or choroid. All patients underwent tumor biopsy for GEP prognostic testing. Clinicopathol

SUBMITTER: Walter SD 

PROVIDER: S-EPMC4966166 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature