Genomic analysis of local variation and recent evolution in Plasmodium vivax.

ABSTRACT: The widespread distribution and relapsing nature of Plasmodium vivax infection present major challenges for the elimination of malaria. To characterize the genetic diversity of this parasite in individual infections and across the population, we performed deep genome sequencing of >200 clinical samples collected across the Asia-Pacific region and analyzed data on >300,000 SNPs and nine regions of the genome with large copy number variations. Individual infections showed complex patterns of genetic structure, with variation not only in the number of dominant clones but also in their level of relatedness and inbreeding. At the population level, we observed strong signals of recent evolutionary selection both in known drug resistance genes and at new loci, and these varied markedly between ge

SUBMITTER: Pearson RD 

PROVIDER: S-EPMC4966634 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature