Common position of indels that cause deviations from canonical genome organization in different measles virus strains.

ABSTRACT:

Background

The canonical genome organization of measles virus (MV) is characterized by total size of 15 894 nucleotides (nts) and defined length of every genomic region, both coding and non-coding. Only rarely have reports of strains possessing non-canonical genomic properties (possessing indels, with or without the change of total genome length) been published. The observed mutations are mutually compensatory in a sense that the total genome length remains polyhexameric. Although programmed and highly precise pseudo-templated nucleotide additions during transcription are inherent to polymerases of all viruses belonging to family Paramyxoviridae, a similar mechanism that would serve to non-randomly correct genome length, if an indel has occurred during replication, has so far not b

SUBMITTER: Ivancic-Jelecki J 

PROVIDER: S-EPMC4966754 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature