The application of mathematical modelling to the design of bispecific monoclonal antibodies.

ABSTRACT: Targeting multiple receptors with bispecific antibodies is a novel approach that may prevent the development of resistance to cancer treatments. Despite the initial promise, full clinical benefit of this technology has yet to be realized. We hypothesized that in order to optimally exploit bispecific antibody technology, thorough fundamental knowledge of their pharmacological properties compared to that of single agent combinations was needed. Therefore, we developed a mathematical model for the binding of bispecific antibodies to their targets that accounts for the spatial distribution of the binding receptors and the kinetics of binding, and is scalable for increasing valency. The model provided an adequate description of internal and literature-reported in vitro data on bispecific bindin

SUBMITTER: van Steeg TJ 

PROVIDER: S-EPMC4966826 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature