Circulating Levels of Irisin in Hypopituitary and Normal Subjects.

ABSTRACT:

Context

The recently identified myokine irisin conveys some of the benefits of exercise. Hypopituitarism with adult growth hormone deficiency (HP) is a situation characterized by decreased GH secretion and an altered body composition.

Objective

Our aim was to study the skeletal muscle hormone irisin in HP, and compare the results with a similar group of normal subjects.

Participants and methods

Seventeen HP patients and fifty-one normal subjects of similar age and sex were studied. The diagnosis of GH deficiency was confirmed by the presence of pituitary disease and a peak GH secretion below 3 μg/L after an insulin tolerance test. The patients were adequately treated for all pituitary hormone deficits, except for GH. Fasting serum irisin was measured with an enzyme im

SUBMITTER: Pena-Bello L 

PROVIDER: S-EPMC4966893 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature