Altered gut microbiota in Rett syndrome.

ABSTRACT:

Background

The human gut microbiota directly affects human health, and its alteration can lead to gastrointestinal abnormalities and inflammation. Rett syndrome (RTT), a progressive neurological disorder mainly caused by mutations in MeCP2 gene, is commonly associated with gastrointestinal dysfunctions and constipation, suggesting a link between RTT's gastrointestinal abnormalities and the gut microbiota. The aim of this study was to evaluate the bacterial and fungal gut microbiota in a cohort of RTT subjects integrating clinical, metabolomics and metagenomics data to understand if changes in the gut microbiota of RTT subjects could be associated with gastrointestinal abnormalities and inflammatory status.

Results

Our findings revealed the occurrence of an intestinal sub-inf

SUBMITTER: Strati F 

PROVIDER: S-EPMC4967335 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature