Genetic variation associated with preterm birth in African-American women.

ABSTRACT:

Background

Preterm birth is considered a multifactorial condition; however, emerging evidence suggests that genetic variation among individuals may have an important role. Prior studies have suggested that single-nucleotide polymorphisms associated with genes related to the immune system, and particularly the maternal inflammatory response, may be associated with an increased risk of preterm delivery.

Objective

The objective of the study was to identify single-nucleotide polymorphisms associated with spontaneous preterm birth <37 weeks within a cohort of African-American women.

Study design

This is a secondary analysis of a randomized trial that evaluated periodontal disease and preterm birth. Women were enrolled between 6 and 20 weeks' gestation at 3 prenatal care cl

SUBMITTER: Frey HA 

PROVIDER: S-EPMC4967390 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature