Age decreases mitochondrial motility and increases mitochondrial size in vascular smooth muscle.

ABSTRACT:

Key points

Age is proposed to be associated with altered structure and function of mitochondria; however, in fully-differentiated cells, determining the structure of more than a few mitochondria at a time is challenging. In the present study, the structures of the entire mitochondrial complements of cells were resolved from a pixel-by-pixel covariance analysis of fluctuations in potentiometric fluorophore intensity during 'flickers' of mitochondrial membrane potential. Mitochondria are larger in vascular myocytes from aged rats compared to those in younger adult rats. A subpopulation of mitochondria in myocytes from aged, but not younger, animals is highly-elongated. Some mitochondria in myocytes from younger, but not aged, animals are highly-motile. Mitochondria that are motile ar

SUBMITTER: Chalmers S 

PROVIDER: S-EPMC4967731 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature