Nrf2 signalling and autophagy are involved in diabetes mellitus-induced defects in the development of mouse placenta.

ABSTRACT: It is widely accepted that diabetes mellitus impairs placental development, but the mechanism by which the disease operates to impair development remains controversial. In this study, we demonstrated that pregestational diabetes mellitus (PGDM)-induced defects in placental development in mice are mainly characterized by the changes of morphological structure of placenta. The alteration of differentiation-related gene expressions in trophoblast cells rather than cell proliferation/apoptosis is responsible for the phenotypes found in mouse placenta. Meanwhile, excess reactive oxygen species (ROS) production and activated nuclear factor erythroid2-related factor 2 (Nrf2) signalling were observed in the placenta of mice suffering from PGDM. Using BeWo cells, we also demonstrated that excess RO

SUBMITTER: He MY 

PROVIDER: S-EPMC4967824 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature