Distinct effects of inflammation on preconditioning and regeneration of the adult zebrafish heart.

ABSTRACT: The adult heart is able to activate cardioprotective programmes and modifies its architecture in response to physiological or pathological changes. While mammalian cardiac remodelling often involves hypertrophic expansion, the adult zebrafish heart exploits hyperplastic growth. This capacity depends on the responsiveness of zebrafish cardiomyocytes to mitogenic signals throughout their entire life. Here, we have examined the role of inflammation on the stimulation of cell cycle activity in the context of heart preconditioning and regeneration. We used thoracotomy as a cardiac preconditioning model and cryoinjury as a model of cardiac infarction in the adult zebrafish. First, we performed a spatio-temporal characterization of leucocytes and cycling cardiac cells after thoracotomy. This anal

SUBMITTER: de Preux Charles AS 

PROVIDER: S-EPMC4967830 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature