Survival from Differentiated Thyroid Cancer: What Has Age Got to Do with It?

ABSTRACT:

Background

In most staging systems, 45 years of age is used to differentiate low risk thyroid cancer from high risk thyroid cancer. However, recent studies have questioned both the precise 45 year age point and the concept of using a binary cut off as accurate predictors of disease specific mortality.

Methods

A cohort of 3664 thyroid cancer patients that received surgery and adjuvant treatment at Memorial Sloan Kettering Cancer Center (MSKCC) from the years 1985 to 2010 were analyzed to determine the significance of age at diagnosis as a categorical variable at a variety of age cutoffs (5 year intervals between 30 and 70 years of age). The unadjusted and adjusted hazard ratio for the association between disease-specific survival and age was determined using a Cox proportiona

SUBMITTER: Ganly I 

PROVIDER: S-EPMC4968282 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature