Limited Effects of Type I Interferons on Kyasanur Forest Disease Virus in Cell Culture.

ABSTRACT:

Background

The tick-borne flavivirus, Kyasanur Forest disease virus (KFDV) causes seasonal infections and periodic outbreaks in south-west India. The current vaccine offers poor protection with reported issues of coverage and immunogenicity. Since there are no approved prophylactic therapeutics for KFDV, type I IFN-α/β subtypes were assessed for antiviral potency against KFDV in cell culture.

Methodology/principal findings

The continued passage of KFDV-infected cells with re-administered IFN-α2a treatment did not eliminate KFDV and had little effect on infectious particle production whereas the IFN-sensitive, green fluorescent protein-expressing vesicular stomatitis virus (VSV-GFP) infection was controlled. Further evaluation of the other IFN-α/β subtypes versus KFDV infecti

SUBMITTER: Cook BW 

PROVIDER: S-EPMC4968803 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature