Immunological Evidence for the Role of Mycobacteria in Sarcoidosis: A Meta-Analysis.

ABSTRACT:

Background

Sarcoidosis is a granulomatous disease, the etiology of which is currently unknown. The role of mycobacteria in the etiology of sarcoidosis has been extensively investigated. In this meta-analysis, we assessed the immunological evidence of the possible role of mycobacteria in the pathogenesis and development of sarcoidosis.

Methods

We performed a systematic search of relevant articles from PubMed, Embase and Cochrane Library databases published between January 1990 and October 2015. Data extracted from the articles were analyzed with Review Manager 5.3 (Cochrane Collaboration, Oxford, UK).

Results

In this meta-analysis, 13 case-control studies (733 participants) were considered eligible according to our criteria. Methodological quality was assessed using th

SUBMITTER: Fang C 

PROVIDER: S-EPMC4968811 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature