Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status.

ABSTRACT: Sirtuins (SIRT) belonging to the NAD+ dependent histone deacetylase III class of enzymes have emerged as master regulators of metabolism and longevity. However, their role in prevention of organismal aging and cellular senescence still remains controversial. In the present study, we now report upregulation of SIRT2 as a specific feature associated with stress induced premature senescence but not with either quiescence or cell death. Additionally, increase in SIRT2 expression was noted in different types of senescent conditions such as replicative and oncogene induced senescence using multiple cell lines. Induction of SIRT2 expression during senescence was dependent on p53 status as depletion of p53 by shRNA prevented its accumulation. Chromatin immunoprecipitation revealed the presence of

SUBMITTER: Anwar T 

PROVIDER: S-EPMC4968900 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature