Aspirin Use and Incident Cardiovascular Disease, Kidney Failure, and Death in Stable Kidney Transplant Recipients: A Post Hoc Analysis of the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) Trial.

ABSTRACT:

Background

Cardiovascular disease (CVD) is the leading cause of death in kidney transplant recipients. Whether aspirin may reduce the risk for CVD, death, and kidney failure outcomes is uncertain.

Study design

Post hoc cohort analysis of FAVORIT, a randomized trial examining the effect of homocysteine-lowering vitamins on CVD in kidney transplant recipients.

Setting & participants

Prevalent adult kidney transplant recipients with hyperhomocysteinemia and stable kidney function from the United States, Canada, and Brazil participating in FAVORIT, with no known history of CVD.

Predictor

Aspirin use, with aspirin users matched to nonusers using a propensity score.

Outcomes

Incident CVD events, kidney failure, all-cause mortality, a composite of CVD events or

SUBMITTER: Dad T 

PROVIDER: S-EPMC4969122 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature