Scheduled, intermittent stimulation of the thalamus reduces tics in Tourette syndrome.

ABSTRACT:

Introduction

Personalized, scheduled deep brain stimulation in Tourette syndrome (TS) may permit clinically meaningful tic reduction while reducing side effects and increasing battery life. Here, we evaluate scheduled DBS applied to TS at two-year follow-up.

Methods

Five patients underwent bilateral centromedian thalamic (CM) region DBS. A cranially contained constant-current device delivering stimulation on a scheduled duty cycle, as opposed to the standard continuous DBS paradigm was utilized. Baseline vs. 24-month outcomes were collected and analyzed, and a responder analysis was performed. A 40% improvement in the Modified Rush Tic Rating Scale (MRTRS) total score or Yale Global Tic Severity Scale (YGTSS) total score defined a full responder.

Results

Three of the

SUBMITTER: Rossi PJ 

PROVIDER: S-EPMC4969169 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature